Tilapia is one of the most popular fish species for farming and is second in terms of volume after carps. WorldFish has been working for decades on fish genetic improvement and dissemination activities across Asia and Africa. Building on this knowledge, the WorldFish Strategy (2017–2022) and CGIAR Research Program on Fish Agri-Food Systems (FISH) (2017–2022) are providing a combination of support to accelerate fish breeding, and improvement programs and increasing the impact of dissemination of improved fish breeds. Part of the approach is also to produce resources for better management practices (BMPs) to support sustainable farming of tilapia. This training manual for smallholders in Zambia growing tilapia in pond-based systems is one of the products developed under this approach. It is an output of the Aquaculture Technical Vocational and Entrepreneurship Training for Improved Private and Smallholder Skills (AQ TEVET) project.